Showing posts with label surveys. Show all posts
Showing posts with label surveys. Show all posts

Tuesday, 2 June 2015

Princess Health and Say It Ain't So, Again - a "Push Poll" to Minimize the Hazards of Conflicts of Interest ...in the New England Journal of Medicine?. Princessiccia

Princess Health and Say It Ain't So, Again - a "Push Poll" to Minimize the Hazards of Conflicts of Interest ...in the New England Journal of Medicine?. Princessiccia

The New England Journal of Medicine recently published a remarkable series of apologiae for conflicts of interest,(1-4) about which we have published three posts, here, here, and here.  Just to ice the cake, the NEJM also set up a reader poll on the subject. Its introduction stated,

we invite you to put yourself in the role of editor and help us decide about the suitability of three hypothetical potential authors of review articles for the Journal.

However, as noted first in a post on the HealthNewsReview.org blog, the poll had a curious design. 

Each of the three hypothetical experts has some type of financial arrangement with the pharmaceutical industry � either royalty payments, speaking fees, or commercially supported research at a university that covers everything except the researcher�s salary.

Noticeably absent was a 'Case #4' describing a potential author with no conflict of interest. 

IMHO, this seems like a biased survey design.  By failing to incorporate a questions about an unconflicted author, the numeric results of the poll could not show whether those answering it would actually favor authors without conflicts of interest.  Of course, the whole thrust of the three commentary(2-4) plus one editorial(1) NEJM series was that concerns about such conflicts are overblown.

Nonetheless, the poll allowed for comments, and as the blog post showed, this bias did not escape notice.  One commentator, Dr David Newman, wrote

The only reason to choose any of the individuals in these cases would be if there were no available alternatives.

This survey bias did not escape Dr Josh Farkas, who wrote this in a PulmCrit blog post,

Perhaps the most interesting component of the media campaign is the reader poll about the adequacy of various hypothetical authors for a review article.  Three potential authors are described, all of whom have significant COIs.  The design of this poll itself is biased, by presenting no authors without COIs.  A more transparent approach might be to simply ask readers 'do you think review article authors should be allowed to have COIs?'

Thus, the NEJM conflict of interest poll appears to be not an attempt at unbiased data collection, but a "push poll."  A "push poll," per Wikipedia, is:

an interactive marketing technique, most commonly employed during political campaigning, in which an individual or organization attempts to influence or alter the view of voters under the guise of conducting a poll.

By prominently publishing a poll with such a biased design, the NEJM has further supported my argument that its current editors are engaging in polemics rather than scholarly debate about the very important issue of conflicts of interest in medicine and health care.  Perhaps the current NEJM editors should consider joining the blogsphere in which polemics abound, while leaving the serious business of scholarly journal editing to those who are more dispassionate.   

References
1.Drazen JM.  Revisiting the commercial-academic interface.  N Eng J Med 2015; ; 372:1853-1854. Link here.
2. Rosenbaum L.  Reconnecting the dots - reinterpreting industry-physician relations.  N Eng J Med 2015; 372:1860-1864.  Link here.
3. Rosenbaum L. Understanding bias - the case for careful study.  N Engl J Med 2015;  372:1959-1963.  Link here.
4.  Rosenbaum L.  Beyond moral outrage - weighing the trade-offs of COI regulation. N Engl J Med 2015; 372: 2064-2068.  Link here.

Friday, 24 June 2005

Princess Health and An Australian Survey of Threats to Research Integrity. Princessiccia

Princess Health and An Australian Survey of Threats to Research Integrity. Princessiccia

Another important article on threats to the integrity of clinical research has appeared in the Medical Journal of Australia. (Henry DA et al. Medical specialists and pharmaceutical industry-sponsored research: a survey of the Australian experience. Med J Aust 2005; 182: 557-560.)
The authors sent a survey to 5000 Australian specialists, excluding general practitioners, but also surgeons and anesthesologists, and obtained a 39% response rate. 388 specialists (41% of respondents) had done pharmaceutical industry sponsored research. Of these,
  • 100 (25.7% of those engaging in research) reported that the first draft of a research report was written by pharmaceutical company or contract research organization personnel
  • 55 (14.2%) reported a delay in presentation or publication of key study findings
  • 41 (10.6%) reported failure to publish key findings
  • 22 (5.7%) reported editing of the report to make the drug appear better than was justified by the study results
  • 18 (4.6%) reported concealment of relevant findings.
This study suggests that manipulation and suppression of research results in favor of commercial research sponsors' products is an international pheonomenon, and one that involves not only academic researchers but those in private practice.
An accompanying editorial (Gotzsche PC. Research integrity and pharmaceutical industry sponsorship. Med J Aust 2005; 182: 549-550) suggested that "testing drugs in patients" should be "a public enterprise." It asked, "who would buy a washing machine that is five or 10 times more expensive than other washing machines just because its manufacturer has compared it with other machines and claims that it is the best?"
Thanks to Sue Pelletier's Capsules blog for the tip.
Princess Health and  An Australian Survey of Threats to Research Integrity.Princessiccia

Princess Health and An Australian Survey of Threats to Research Integrity.Princessiccia

Another important article on threats to the integrity of clinical research has appeared in the Medical Journal of Australia. (Henry DA et al. Medical specialists and pharmaceutical industry-sponsored research: a survey of the Australian experience. Med J Aust 2005; 182: 557-560.)
The authors sent a survey to 5000 Australian specialists, excluding general practitioners, but also surgeons and anesthesologists, and obtained a 39% response rate. 388 specialists (41% of respondents) had done pharmaceutical industry sponsored research. Of these,
  • 100 (25.7% of those engaging in research) reported that the first draft of a research report was written by pharmaceutical company or contract research organization personnel
  • 55 (14.2%) reported a delay in presentation or publication of key study findings
  • 41 (10.6%) reported failure to publish key findings
  • 22 (5.7%) reported editing of the report to make the drug appear better than was justified by the study results
  • 18 (4.6%) reported concealment of relevant findings.
This study suggests that manipulation and suppression of research results in favor of commercial research sponsors' products is an international pheonomenon, and one that involves not only academic researchers but those in private practice.
An accompanying editorial (Gotzsche PC. Research integrity and pharmaceutical industry sponsorship. Med J Aust 2005; 182: 549-550) suggested that "testing drugs in patients" should be "a public enterprise." It asked, "who would buy a washing machine that is five or 10 times more expensive than other washing machines just because its manufacturer has compared it with other machines and claims that it is the best?"
Thanks to Sue Pelletier's Capsules blog for the tip.

Saturday, 2 April 2005

Princess Health and Major ACPE Survey on Unethical Business Practices in US Health Care. Princessiccia

Princess Health and Major ACPE Survey on Unethical Business Practices in US Health Care. Princessiccia

The results of a very important survey have just been published by the American College of
Physician Executives (ACPE)
. A summary of survey data is here. The full article, entitled "Unethical Business Practices in US Health Care Alarm Physician Leaders," is here. An American Medical News article summarizing some aspects of the results is here.
Basically the ACPE designed the survey to determine "how have physicians - along with other health care providers - responded to the universal seep of commercial imperatives into the modern practice of medicine." It surveyed about 1500 ACPE members (a 21% response rate). Of those responding, 10.1% were CEOs or the like, 28.8% were at the vice-president, CMO, COO, CIO level or similar, 17.9% were medical directors, 24.5% had academic leadership positions, and 18.6% were practicing physicians, consultants, or house-staff.
The results that were most striking and relevant to the issue of external threats to physicians' professionalism were as follows.
  • A large majority of respondents were quite concerned about "unethical business practices affecting US health care today." (54.6% were very concerned, 35.6% were moderately concerned).
  • Significant proportions of responders were concerned about unethical business practices within their own organization. (33.1% thought that there were one or more physicians in the organization "involved in unethical business practices;" 11% thought there was a board member "involved in unethical business practices;" 14.2% thought there was a non-physician administrator "involved in unethical business practices.")
  • The majority, 53.8%, could identify another health care organization in their community "involved in unethical business practices."
  • Although most, 70.1%, said that their organization had a written code of ethical behavior, only 59.7% of them said the code was actually enforced.
  • A large majority, 80.8% agreed that "professional organizations need to promote tougher ethical standards."
  • Most respondents evinced concern about a variety of unethical practices by physicians. In addition, most were concerned about board members or non-physician executives with conflicts of interest (33% very concerned, 33% moderately concerned about the former, 34% and 32%, the latter.) Most were concerned about board members or non-physician executives accepting gifts from vendors (27% and 29% re the former, 34% and 32% re the latter.)
  • Finally, when asked who was responsible "for sowing the minefield through which today's physicians have to try to pick a righteous path," they named a variety of types of large health care organizations, health care plans and health insurers, pharmaceutical and device manufacturers, hospitals and health system, and malpractice attorneys.
  • Finally, respondents provided some pithy comments."Our health care system is designed to encourage unethical behavior by its misplaced financial priorities." "Current medical practice on a corporate level is schizophrenic." "Ultimately, the bottom line corrupts absolutely!" "'Business ethics'... an oxymoron?"
In summary, although its small response rate is a limitation, this survey begins to quantitate the scope of some of the issues we have discussed on Health Care Renewal. It suggests that our concerns about threats to physicians' professionalism due to concentration and abuse of power are not exaggerated. If physician executives are this worried, it suggests that doctors in the trenches may be even more so.
Now the question is how can we get the folks with these concerns together, and figure out what to do about them?
Princess Health and  Major ACPE Survey on Unethical Business Practices in US Health Care.Princessiccia

Princess Health and Major ACPE Survey on Unethical Business Practices in US Health Care.Princessiccia

The results of a very important survey have just been published by the American College of
Physician Executives (ACPE)
. A summary of survey data is here. The full article, entitled "Unethical Business Practices in US Health Care Alarm Physician Leaders," is here. An American Medical News article summarizing some aspects of the results is here.
Basically the ACPE designed the survey to determine "how have physicians - along with other health care providers - responded to the universal seep of commercial imperatives into the modern practice of medicine." It surveyed about 1500 ACPE members (a 21% response rate). Of those responding, 10.1% were CEOs or the like, 28.8% were at the vice-president, CMO, COO, CIO level or similar, 17.9% were medical directors, 24.5% had academic leadership positions, and 18.6% were practicing physicians, consultants, or house-staff.
The results that were most striking and relevant to the issue of external threats to physicians' professionalism were as follows.
  • A large majority of respondents were quite concerned about "unethical business practices affecting US health care today." (54.6% were very concerned, 35.6% were moderately concerned).
  • Significant proportions of responders were concerned about unethical business practices within their own organization. (33.1% thought that there were one or more physicians in the organization "involved in unethical business practices;" 11% thought there was a board member "involved in unethical business practices;" 14.2% thought there was a non-physician administrator "involved in unethical business practices.")
  • The majority, 53.8%, could identify another health care organization in their community "involved in unethical business practices."
  • Although most, 70.1%, said that their organization had a written code of ethical behavior, only 59.7% of them said the code was actually enforced.
  • A large majority, 80.8% agreed that "professional organizations need to promote tougher ethical standards."
  • Most respondents evinced concern about a variety of unethical practices by physicians. In addition, most were concerned about board members or non-physician executives with conflicts of interest (33% very concerned, 33% moderately concerned about the former, 34% and 32%, the latter.) Most were concerned about board members or non-physician executives accepting gifts from vendors (27% and 29% re the former, 34% and 32% re the latter.)
  • Finally, when asked who was responsible "for sowing the minefield through which today's physicians have to try to pick a righteous path," they named a variety of types of large health care organizations, health care plans and health insurers, pharmaceutical and device manufacturers, hospitals and health system, and malpractice attorneys.
  • Finally, respondents provided some pithy comments."Our health care system is designed to encourage unethical behavior by its misplaced financial priorities." "Current medical practice on a corporate level is schizophrenic." "Ultimately, the bottom line corrupts absolutely!" "'Business ethics'... an oxymoron?"
In summary, although its small response rate is a limitation, this survey begins to quantitate the scope of some of the issues we have discussed on Health Care Renewal. It suggests that our concerns about threats to physicians' professionalism due to concentration and abuse of power are not exaggerated. If physician executives are this worried, it suggests that doctors in the trenches may be even more so.
Now the question is how can we get the folks with these concerns together, and figure out what to do about them?