Showing posts with label overweight. Show all posts
Showing posts with label overweight. Show all posts

Tuesday, 10 May 2016

Princess Health and Why some dogs (and humans) are born hungry. Princessiccia

Princess Health and Why some dogs (and humans) are born hungry. Princessiccia

The brain is the central regulator of appetite and body fatness, and genetic variation that affects body fatness tends to act in the brain. One important site of variation is the POMC gene, which codes for a signaling molecule that suppresses food intake. A new study shows that Labrador retrievers often carry an inactive version of the POMC gene, causing them to be highly food motivated, obesity-prone-- and perhaps more easily trainable.

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Saturday, 9 January 2016

Princess Health and Always Hungry? It's Probably Not Your Insulin.. Princessiccia

Princess Health and Always Hungry? It's Probably Not Your Insulin.. Princessiccia

David Ludwig, MD, recently published a new book titled Always Hungry? Conquer cravings, retrain your fat cells, and lose weight permanently. The book is getting widespread media coverage. Ludwig is a professor of pediatrics at the Harvard Medical School and a professor of nutrition at the Harvard School of Public Health. He's a pediatric endocrinologist, but his primary focus is research, particularly the impact of nutrition on hunger, calorie expenditure, and body weight. Although I sometimes disagree with how he interprets evidence, he has made significant and useful contributions to the scientific literature in these areas, and I also support his efforts to find policy solutions to curb the intake of sweetened beverages and other junk foods. In the grand scheme of things, he's an ally in the fight to improve the American diet.

Ludwig has written several high-profile op-ed pieces in recent years, both in the popular press and in scientific journals (1, 2). He argues that our understanding of eating behavior and obesity may be all wrong, and that our focus on calories may be leading us away from the true cause of obesity: hormonal imbalance. And the primary culprit is insulin. You might recognize this idea, because it's similar to the one that science journalist Gary Taubes developed in his book Good Calories, Bad Calories.

According to this view, overeating is irrelevant. We gain fat because our insulin levels are too high, leading our fat tissue to take up too much fat, and other tissues to take up too much glucose, causing our blood energy levels to drop and resulting in fat gain, hunger, and fatigue. The ultimate cause of the problem is the rapidly-digesting carbohydrate and sugar we eat. This idea is encapsulated by Ludwig's quote, "Overeating doesn't make you fat. The process of getting fat makes you overeat" (3).

Here are eleven facts that may make you question this line of reasoning:
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Thursday, 10 December 2015

Princess Health and New Evidence Strengthens the Link Between Hypothalamic Injury, Obesity, and Insulin Resistance. Princessiccia

Princess Health and New Evidence Strengthens the Link Between Hypothalamic Injury, Obesity, and Insulin Resistance. Princessiccia

Obesity involves changes in the function of brain regions that regulate body fatness and blood glucose, particularly a region called the hypothalamus. My colleagues and I previously showed that obesity is associated with inflammation and injury of the hypothalamus in rodent models, and we also presented preliminary evidence that the same might be true in humans. In our latest paper, we confirm this association, and show that hypothalamic injury is also associated with a marker of insulin resistance, independently of BMI.

Introduction

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Monday, 16 November 2015

Princess Health and Carbohydrate, Sugar, and Obesity in America. Princessiccia

Princess Health and Carbohydrate, Sugar, and Obesity in America. Princessiccia

We like explanations that are simple, easy to understand, and explain everything. One example of this is the idea that eating carbohydrate, or sugar, is the primary cause of obesity. This lets us point our finger at something concrete and change our behavior accordingly. And it's true enough that it has practical value. But the world around us often turns out to be more complex than we'd like it to be.

The CDC recently released its latest data on the prevalence of obesity in the US, spanning the years 2013-2014 (1). These data come from its periodic National Health and Nutrition Examination Surveys (NHANES). Contrary to what many of us had hoped for after a slight decline in obesity in the last survey, the prevalence has once again increased. Today, roughly 38 percent of US adults have obesity. As a nation, we're continuing to gain fat, which is extremely concerning.

I decided to examine the relationship between obesity prevalence and our intake of carbohydrate and sugar over the years. The food intake data come from the USDA's Economic Research Service (2). For some reason, the data on carbohydrate don't extend beyond 2010. This probably relates to funding cuts at the USDA*.

Let's have a look at the data for carbohydrate:

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Friday, 16 October 2015

Wednesday, 26 August 2015

Princess Health and How Much Does Sugar Contribute to Obesity?. Princessiccia

Last week, the British Medical Journal published a review article titled "Dietary Sugars and Body Weight", concluding that "free sugars" and sugar-sweetened beverages contribute to weight gain. But what are "free sugars", and why does the scientific literature suggest that the relationship between sugar intake and body weight isn't as straightforward as it may initially appear?




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Thursday, 13 August 2015

Princess Health and A New Human Trial Undermines the Carbohydrate-insulin Hypothesis of Obesity, Again. Princessiccia

Princess Health and A New Human Trial Undermines the Carbohydrate-insulin Hypothesis of Obesity, Again. Princessiccia

The carbohydrate-insulin hypothesis of obesity states that carbohydrates (particularly refined carbohydrates and sugar) are the primary cause of obesity due to their ability to increase circulating insulin, and that the solution to obesity is to restrict carbohydrate intake. Numerous studies have tested this hypothesis, more or less directly, in animals and humans. Despite the fact that many of these studies undermine the hypothesis, it remains extremely popular, both in the popular media and to a lesser extent among researchers. A new human trial by Kevin Hall's research team at the US National Institutes of Health offers very strong evidence that the carbohydrate-insulin hypothesis of obesity is incorrect. At the same time, it offers surprising and provocative results that challenge prevailing ideas about diet and weight loss.



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